Application
model system to study the pathophisiology of rheumatoid arthritis, matrix mineralization, effects of inflammatory mediators, bone morphogenic proteins, bone remodeling and metabolism
Cell Line Origin
Bone
Components
Basal Medium containing 10% FBS & 10% DMSO
General description
Human Osteoblasts-Rheumatoid Arthritis, HOb-RA, are isolated from bone of patients with rheumatoid arthritis (RA) and provide an excellent model system to study the patophisiology of that disease in vitro, including matrix mineralization, effects of inflammatory mediators and bone morphogenic proteins, physiological control of bone remodeling and regulation of bone metabolism.Characterization: Positive for bone mineralization.
Preparation Note
2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO Can be cultured at least 10 doublings
Subculture Routine
Please refer to the HOb-RA Culture Protocol.
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